Bee venom is the predominant ingredient within the BEEONICA^® face and neck cosmetic solution.
It is extracted by hand only once a year in midsummer, a period which the bee is in its greatest vigor.
The venom is produced by two venom glands inside the abdomen and is expelled through the stinger.
With the help of non-invasive micro-pulses, bees are stimulated on a sensory level so they can release the venom naturally and painlessly [PIC. 1], which will be produced again after four days.
The poison is collected and crystallized within one hour of [PIC. 2] oxygenation, immediately lyophilized freeze-dried [PIC. 3] and introduced fresh over forty-eight hours into the BEEONICA^® face and neck cream to preserve its qualities [PIC. 4].

The production of one gram of bee venom requires ten thousand “ stings”, this process makes it nine times more expensive than gold.

On the dermis it creates a lifting effect similar to the result obtained from botulinum injections.
This filler action clinically improves the marks (signs) on the face and neck, promotes the relaxation of the facial muscles and visibly reduces expression lines, their average depth and size: the skin appears toned, elastic and youthful.
In fact, bee venom is mainly composed of a powerful peptide called melittin which massively induces the reproduction of collagen and elastin in the skin thanks to the high percentage inserted inside the BEEONICA^® cream developed in collaboration with the TNHL laboratory at the Polytechnic University of Turin.

Furthermore, being an effective anti-inflammatory, it acts on the skin by providing a decisive decrease in acne, skin blemishes, scars, macro impurities and improves the healing of skin wounds and burns.

Discovered in the 5th century BC, bee venom remains to this day the best solution to eliminate the signs of aging from the face.

We collect the honey at the end of July in the territory of the typical product “Pragelato Honey Beekeepers Consortium since 1973”.
Honey comes from the nectar of flowers and is produced by bees. It is very rich in sugars, polyphenols and flavonoids, it is an ideal active ingredient for the face and neck cosmetic solution BEEONICA^® solution due to its characteristics restorative, emollient, nourishing and antioxidant.
These benefit help combat free radicals, make the skin stronger and more elastic. Honey contains enzymes, antioxidants, and alpha-hydroxy acids that help hydrate soothe and regenerate the skin. Using osmosis, microcirculation is induced in the dermis, which results in better nutrition and oxygenation.
In this way, metabolic processes are also stimulated, which lead the elimination of harmful metabolites, the detoxification of dermal tissue and increased skin regenerative processes. Its antibacterial properties make it effective in fighting acne and reducing skin infections.
Furthermore, it contains natural hydrogen peroxide, making it an equally natural disinfectant.
Xerosis (dry skin) is relieved by the fatty acids and mineral salts found in honey. Thanks to the presence of flavonoids, honey plays an important role in sun protection, helping to prevent skin irritations, as well as chapped and rough skin. Given its properties, it can be used on different skin types, from dry to oily, sensitive, or acne-prone.

In the month of june we collect pollen from the area of the typical product “Pragelato honey beekeepers consortium since 1973”. The texture to the touch is granular and the color varies depending on the pollination of the flowers present in the valley. Harvested by bees in quantities exceeding their needs, we take a portion of it to include in the BEEONICA^®, facial and neck solution, this allows us to benefit from the rich content of vitamin C, proteins, flavonoids, fatty and phenolic acids, phytosterols and mineral salts.
Its greatest effectiveness is seen in the reduction of eczema and psoriasis, and in the regeneration of wounds. it slows the aging of skin cells by stimulating and regenerating the growth of epidermal tissue, while also hydrating and contributing to effective blood circulation.
The Kaempferol contained within it plays a photo protective, antioxidant, and antiinflammatory role. Your face will appear revitalized and elastic to the touch.

Edelweiss is a unique flower created by nature to survive in extreme conditions. Indeed, you can find it in the Alps up to 3.000 meters above sea level. It possesses an incredible fiber that allows it to withstand strong winds, intense cold, and heavy exposure to ultraviolet rays. We collect the flowers from the “Carlo Alberto forestry nursery in Fenestrelle“, during the month of July, when the plant reaches full maturity and is in bloom, and we process it within 12 hours.
To extract its active ingredients, we use ultrasound. This technique allows us to obtain a stable solution, containing most of the bioactive and unaltered components of the plant which we then incorporate into the BEEONICA^® face and neck solution until saturation.
The benefits it offers the skin are linked to the prevention of cellular aging, possible due to the large amount of mixed polyphenols present within it.
Chlorogenic and leontopodic acids types A and B, for example, block the harmful effects of sunlight and counteract the formation of free radicals carrying out a massive anti-aging action. Furthermore, they perform an important inhibitory effect on skin enzymes such as hyaluronidase and collagenase, thus counteracting the loss of muscle tone and the signs of aging.
Edelweiss extract contains flavonoids, which have antioxidant and photo-protective properties that slow down skin aging.
Polysaccharides and amino acids penetrate deep into the skin layer to hydrate, nourish and soften, restoring the skin to its natural barrier effect.
The edelweiss, taking advantage of its multiple phytonutrients essential for fighting UV sunlight, is included in BEEONICA^® formula to protect the skin from solar radiation.

Viper poison, introduced within the BEEONICA^® face and neck solution, is a very synthetic biomimetic tripeptide high-performance, synthesized in a laboratory.
It is the cosmetic alternative to botulinum (botox effect), having a mechanism similar to that of a molecule with paralyzing activities present in the reptile venom. It is a powerful cosmetic active ingredient, the result on the skin is instantaneous, just as viper venom paralyzes its prey, this Syn-Ake polypeptide molecule relaxes muscle contractions by reducing the marks on the dermis by 80% and preventing its formation. This tripeptide is a modulator of neurotransmitter expression and does so by inhibiting the release of acetylcholine receptors. Its action is safe and clinically tested, it does not compromise the expressive capacity of the face and the effects are totally reversible.
Containing amino acids, enzymes, vitamins A and E, it deeply nourishes the dermis by regenerating it with new cells. These cells stimulate the skin’s defense metabolism against external agents slowing down its aging.
The skin becomes smoother and more even, its surface is leveled, and the number and depth of wrinkles are visibly reduced.

Acmella Oleracea is an ancient plant, native to south america and tropical Africa. As with edelweiss, we process the freshly cut flowers of the fresh plant using ultrasound, to preserve all the properties of this miraculous flower.
The main bioactive component is Spilanthol, and alkaloid with analgesic, antioxidant, anti-inflammatory and muscle relaxant properties, it has a titghtening effect and a strong impact on the muscles, with the ability to reach nerve endings transdermally.
Also kown as vegetable botulinum, it stimulates the relaxation of the skin’s fibroblasts with the incredible ability to rapidly and progressively inhibit the repeated contractions of subcutaneous muscles, in particular the facial ones. This provides an instantaneous effect on the reduction of expression lines. Among the chemical constituents found in Acmella Oleracea we mainly find N-alkylamides, terpenoids, coumarins and fatty and phenolic acids. When included In the BEEONICA^® face and neck solution, it helps achieve the almost complete removal of wrinkles around the eyes, eyebrows, lips, forehead and neck.

Resveratrol is added to the BEEONICA^® face and neck solution due to its anti-aging properties, due to its antioxidant, anti-inflammatory and protective role against the endothelium and blood vessels.
Resveratrol is a non-flavonoid polyphenolic phytoalexin, naturally produced by plants, such as grapevines and grape skins, from which it is extracted for the BEEONICA^® face and neck solution.
Several studies have demonstrated the intracellular biological mechanisms linked to the action of resveratrol in acting against free radicals, in particular by inhibiting lipid peroxidation, and in chelating metal ions, reducing oxidative stress events on cells skin and the consequent cell death.
This makes it an excellent component for reducing the effects of photoaging from ultraviolet sunlight.

Hyaluronic acid is included in the BEEONICA^® face and neck formula as an additional key component for maintaining skin hydration and as a plumping agent. Skin aging is also associated with the loss of skin moisture and this molecule has an incredible ability to retain water in the dermal tissue.
This polysaccharide, which belongs to the glycosaminoglycan family and made up of two disaccharides (N- acetylglucosamine and D- glucoronic acid), is naturally present in the tissue, especially in the extracellular matrix of the skin, in different molecular forms, where it regulates water balance, osmotic pressure and ion flow in cells. With aging, its presence tends to decrease significantly and its integration through BEEONICA^® face and neck cream is therefore relevant to restore the skin’s appearance fresh, elastic and young.
Since the molecular weight of this active ingredient influences its ability to penetrate the skin and its related biological properties, it was introduced into the formulation with different weights. The low and very-low-weight fractions ensure deep hydration thanks to their hygroscopic action and promote cell regeneration. The high weight ones, however, form a viscoelastic film which retains moisture on the skin’s surface, limiting water evaporation.

Collagen is naturally present in the dermis, synthesized by fibroblast cells.
The primary function of collagen is to maintain skin and regular homeostasis cutaneous extracellular matrix. As we age, the amount of collagen produced is reduced or degrades faster due to increased of oxidative stress, free radicals and inflammation level.
The use of collagen in the BEEONICA^® face and neck cream is, therefore, an excellent strategy for plumping the dermal tissue, helping its regeneration and reduces wrinkles and expression lines. Furthermore, the presence of collagen in turn prevents the reduction of elastin and fibronectin from the extracellular matrix of the skin, keeping it elastic and hydrated.

Bakuchiol is a meroterpene phenol, derived from the seed and leaves of the indian plant psoralen corylifolia, also known as Babchi. it has the same functions as retinol, promoting a similar regulation of gene expression and therefore of the protein synthesis of type I, III and IV collagen, but compared to retinol, it has no side effects in terms of skin irritability.
The results after 12 weeks of treatment showed a significant reduction in expression lines, wrinkles, pigmentation, with an increase in elasticity, compactness and overall reduction in photoaging damage, without the usual undesirable side effects associated with retinol treatment.
Thanks to these excellent properties, high tolerability and effectiveness, Bakuchiol is added to the BEEONICA^® face and neck solution to restore the skin’s smoothness both visually and to the touch, as well as radiance and hydration, for an overall anti-aging effect.